Estradiol Valerate Injection is used in hormone therapy, and is an estrogen medication. It is also used in treating the patients for prostate cancer.
Hormonal birth prevention, menopausal symptoms, hormone therapy for transgender people etc is what it is used for among other things.
One can take this oral, or by an injection into muscle, however your doctor prescribes it, depending upon the condition.
There are many uses of estradiol valerate injection as per doctor’s recommendation. Generally it is used as a high dosage of estrogen therapy to treat prostate cancer in men and for hormonal therapy in transgender women.
Where as, low dosage estradiol valerate is used in treating breast cancer in women.
Not only that, estradiol valerate injection has been used to reduce sex drive of offenders.
What is Estradiol Valerate Injection?
It is popularly known as E2V in the medical industry.
Estradiol is also known to be a natural hormone that flows endogenously in the human body.
It also serve as the major female sexual hormone.
Estradiol Valerate Injection, contains a long acting estrogen in sterile oil solutions for intramuscular use.
You can get it, as it’s commercially available as the drug Delestrogen in injection form.
It is mainly responsible for the developing and maintaining female reproductive system and sexual features.
This injection is usually indicated in the treatment for menopausal symptoms or vulvar and vaginal atrophy which is also associated with menopause in older women.
However, from a medical point of view it should not be prescribed to women with the following medical conditions:
- Are not diagnosed with abnormal bleeding in genitals.
- Has had a history of breast cancer.
- Have liver dysfunction or any disease.
- Are suspected of pregnancy
How does Estradiol Valerate work?
It is mainly produced as an ester side chain as, on its own, it has very low bioavailability.
It is known that esterification of the estradiol valerate improves lipophilicity and sustain release via depot intramuscular injection of the fluids.
It is thus considered to be a biological form of estrogen, aiming to improve endogenous estrogen levels within the human body.
Ovarian follicle acts as the primary source of estrogen in cycling out adult women, which, depending upon the phase of a woman’s menstrual cycle, is known to secrete 70-500 mcg of estrogen daily.
Proper and careful administration of estradiol in synthetic and bioidentical forms is known to improve the menopausal symptoms.
Uses of Estradiol Valerate Injection:
As discussed already, estradiol valerate is known to be used for a lot of symptoms related to hormones within the human body.
In addition to that, it is also known to be used in the treatment of prostate cancer in men as high dosage of estrogen. And also in lower quantity for the treatment of breast cancer in women.
Largely known to be given treatment for menopausal symptoms in women and as high dosage of estrogen hormone therapy for transgender women.
It is generally prescribed in cases of abnormal menstrual bleeding, menopausal symptoms, moderate menopausal vulvovaginal atrophy and many more.
Estradiol incorporates it’s effect throughout the body via potent agonism of the Estrogen Receptor, located in various tissues in skin, breasts, bone, fat, prostate, ovaries etc.
What side effects can Estradiol Valerate Injection cause?
If we are to tell you the side effects of Estradiol Valerate Injection in simple terms, it can cause feeling of vomiting, nausea, bloating, headache.
However it is rare that this medication causes severe side effects but in case you experience serious side effects which includes, chest pain, jaw pain, or pain in left arm, heavy sweating, weakness only in one side of the body, severe headache etc, you must not avoid this and consult a healthcare provider immediately.
Common side effects are weight gain, menstrual pain, decrease in appetite, cramps in stomach, nausea, bloating in abdominal region, mood changes, dizziness, diarrhea among others.
In rare and severe cases, due to blood clots it can also cause heart attacks but such cases are rare.
Uncommon side effects are:
Rare but possible severe side effects include a blood clot, breast cancer, heart attack, cancer of the ovary, blocked gall bladder etc.
But as stated, these are rarely observed side effects and do not happen generally. In case, you feel any such symptom, make sure you consult a doctor right away, without wasting any time.
Before using Estradiol Valerate Injection, what precautions should I follow?
Well, this is a must here. You must practice certain precautions before taking Estradiol Valerate Injection.
First and foremost thing to take into consideration is whom to not give this injection, for instance, a woman suspecting pregnancy, or not having unusual genital bleeding. It should be avoided in such cases, so as to prevent any adverse consequences.
In case you are allergic to it or any other thin, you must intimate your doctor about this without any hesitation. Estradiol Valerate Injection may contain ingredients in its formation which might cause allergic reactions in your body and specially if you’re allergic to it, things may turn worse. Which is why, before taking Estradiol Valerate Injection, you must tell your healthcare provider about any allergy you have.
In addition to that, you must also inform your doctor about your medical history specially if it consists of these:
- Breast cancer
- Vaginal bleeding due to unknown reasons
- Symptoms of stroke
- Blood clots due to unusual reasons
- Heart attack
- Liver or Kidney Disease in the past
- History of Seizer or lumps
- Migraine headaches etc
When you consult your doctor about these, they might be able to help you with taking necessary precautions with the Estradiol Valerate Injection.
However, the necessary precautions you must practice before taking Estradiol Valerate Injection includes smoking.
This is because, estrogen when combined with smoking, can increase the chances of high blood pressure, blood clots or even worse, a heart attack. In case you’ve had a surgery or an operation recently, you must tell your doctor, else you might be at a risk of getting chained to a chair or bed for a long time. Not only that, it also includes high risk of blood pressure, clots, heart attack.
Also this medication should never be given to a woman who is pregnant.
Pros and Cons of Using Estradiol Valerate Injection:
Rightly so. Like there are two sides of a coin. We have two aspects of a Estradiol Valerate Injection here as well: The benefits and the side effects.
High doses of Estradiol Valerate is beneficial in the treatment of hormonal therapy in transgender women.
And the low dosage of estrogen is used in the treatment of breast cancer in women and has proven beneficial so far.
Similarly, it helps develop and maintain the female sexual systems and hormones.
While also proving to be helpful in the treatment of prostate cancer in men, with high dosage of Estradiol Valerate.
It helps in the treatment of adult women, specially above 35 years of age who experience menopausal symptoms. With proper and careful administration and consuming prescribed dosages, it can provide long term benefits in the treatment.
However, there are certain precautions that one must practice else the side effects can be adverse. You must expose your medical history or any allergy to your doctor without hesitation if you’re in it for long term benefits.
The pros of Estradiol Valerate Injection could be the side effects that you may experience, which is exactly why it becomes absolutely necessary to intimate complete medical history to your healthcare provider.
It includes risk of high blood pressure, formation of blood clots, which may become the reason for a heart attack, blockages in gall bladder, severe headache, unusual sweating, dryness, heavy breathing, confusion, slipping of tongue etc.
And in such cases, you must rush to your doctor without any delay. Else the consequences can be dire.
Significant Tips And Information You Need To Know
This is a must. You can not risk missing this.
First and foremost, let your doctor know of any allergy that you might have.
Your medical history must be known to your healthcare provider without any concealers.
You’d be required to put yourself in a healthy lifestyle, which also means you have to avoid smoking and drinking alcohol.
This is so because estrogen, if mixed with smoke, can do more damage than any good. It also increases the chances of heart attack, blockages, blood clots etc.
So you need to be extra careful before taking the medication and must practice necessary precautions while you are on the Estradiol Valerate Injection medication for your own good.
One thing to always keep in mind is that you should never self prescribe such a medication, unless your healthcare provider knows everything and has given it a heads up. It can cause more damage than its possible to recover if high doses are consumed without it being administered by a professional healthcare provider.
Estradiol Valerate Injection are available commercially in the form of injection, in combination with another drug.
But it must not be taken by you unless the doctor has medically prescribed you the medication.
Plus, while you’re on these medications, you need to be extra careful. Estradiol Valerate Injection can prove to be beneficial in the hormonal estrogen therapy for transgender women and also the in the treatment of prostate cancer in men and breast cancer in women.
Although the side effects of these medications are usually nominal and nothing to worry about, in case you experience adverse consequences, you should consult your doctor right away, without wasting a moment.
What happens when you inject estradiol valerate?
When you are injected with estradiol valerate you may feel nauseated and experience heavy breathing. Since it is affecting your hormones you might also feel a little heavy inside or headache.
In rare cases, these symptoms may last longer than expected and you must consult your doctor right away in case you are experiencing severe symptoms.
It might also create slip of tongue or confusion. In rarest of the rare cases, it has also become the cause of heart attacks. This is why you should consult your doctor immediately in such cases.
What is the purpose of estradiol valerate?
It is used for balancing female hormones. Not only that, it is also used to give hormonal therapy to transgender women and in treatment of prostate cancer in men and breast cancer in women. Apart from that, it is also used as prime medication in the treatment of menopausal vulvovaginal symptoms.
What foods should you avoid while taking estradiol?
You should not eat grapefruit or drink grapefruit juice as it might change the amount of estradiol that is absorbed in your body.
Along with this, you also need to avoid consuming dairy products, flax seeds, garlic, peaches, meat, alcohol and grain as it might interfere with your hormone levels.
Follow doctor’s advice and prescription precisely to keep your balance of hormones and avoid major side effects.
Does estradiol increase fertility?
It does increase the chances. Some studies were conducted which proves that taking estradiol with letrozole combination has higher success rates than estradiol alone.
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